Malvern zetasizer export data excel
In cancer treatment, the particles must be directed to the tumor site in order to exert their anti-carcinogenic activity, whereas in regenerative medicine, particle-loaded cells or spheroids are directed directly to the target region. Especially in the field of cancer therapy and regenerative medicine, a direct interaction of particles with cells is necessary to achieve a maximum effect. While particles used for blood-pool imaging should preferably not interact with cellular structures, SPIONs intended for MDT or hyperthermia should accumulate in the target area, or be integrated into certain cells or tissues. 1–4 The successful use of SPIONs depends both on the selected application method and on the specific properties of the particles.
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Additionally, the specific surface functionalization can further adapt their biochemical properties and improve targeting in order to treat or visualize certain disease processes. Moreover, their magnetic properties allow the use of directed application techniques such as magnetic drug targeting (MDT) or hyperthermia for the treatment of different diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) play an increasingly important role in the development of improved contrast agents for diagnostic purposes.